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KMID : 0882420040670010049
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Korean Journal of Medicine
2004 Volume.67 No. 1 p.49 ~ p.57
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Effects of bovine colostrum in diclofenac induced gut injured rat model
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Kim Jeong-Wook
Jeon Woo-Kyu
Chun Han-Byul
Kim Young-Choon
Yun Jung-Won
Park Dong-Il
Cho Yong-Kyun
Sung In-Kyung
Park Chang-Young
Sohn Chung-Il
Kim Byung-Ik
Yeom Joon-Sup
Park Hyo-Soon
Sohn Jin-Hee
Kim Eun-Jeong
Shin Myong-Suk
Lee Do-Hyun
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Abstract
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Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed medicine but induce damage throughout the entire gastrointestinal tract including small intestine with protein and blood loss. Impaired epithelial barrier function, overgrowth of luminal bacteria and others have been implicated in the pathogenesis of NSAID induced enteropathy. Colostrum is a first milk produced after birth and is particularly rich in growth factors, immunoglobulins and antimicrobial peptides. The present study aimed to exam whether defatted bovine colostrum reduce small intestinal injury caused by diclofenac in the animals.
Methods: 64 rats were utilized in four groups; control group, diclofenac group, diclofenac with 5% colostrum group and diclofenac with 10% colostrum group. The animals with colostrum were fed with 5% or 10% colostral solution for 5 days before diclofenac administration. Small intestinal injury was induced by administering a single dose of diclofenac (50 mg/kg subcutaneously). Epithelial permeability, enteric aerobic bacterial counts, serum albumin and protein levels, and pathologic findings of distal ileum were measured.
Results: Diclofenac caused marked increase in intestinal permeability, enteric bacterial numbers and intestinal villous damage, and declines in serum levels of total protein and albumin. Co-administration of bovine colostrum reduced intestinal permeability and enteric bacterial numbers, declines in serum albumin and protein levels, and mucosal damage of small intestine induced by diclofenac.
Conclusion: Bovine colostrums may have beneficial effects on preventing NSAID induced small intestinal injury and bacterial translocation.(Korean J Med 67:49-57, 2004)
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KEYWORD
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Non-Steroidal Anti-Inflammatory Drugs, Intestinal Permeability, Bovine Colostrum
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